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“Probably the most said results on serum lipids and lipoproteins seem to be exerted by the oral 17-α-alkylated steroids rather than parenterally administered nandrolone decanoate and testosterone esters.As many of the subjects in study 1 took one or more 17-α-alkylated steroids?that is, methandrostenolone, stanozolol, and oxymetenolone?it seems likely that these agents were responsible for the effects on serum lipids and lipoproteins found in this study. The reduction in serum HDL-C is mediated by hepatic triglyceride lipase, an enzyme that regulates serum lipids.4 Oral AASs stimulate hepatic triglyceride lipase, resulting in decreased serum HDL-C and its subfractions (especially HDL2-C) as well as apo-A1. Parenteral administration of AASs has less profound effects on this enzyme because they enter the circulation without passing through the liver.” |
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