IGF – Organic activation of zirconia surfaces via chemical amendment with IGF-1.

Related Articles Biological activation of zirconia surfaces by chemical modification with IGF-1.

J Biomed Mater Res A. 2015 Apr 7;

Authors: Ito D, Kado T, Nagano-Takebe F, Hidaka T, Endo K, Furuichi Y

Abstract

The purpose of this study was to improve the adhesion and extension of human gingival epithelial cells (HGECs) to the yttria-stabilized zirconia polycrystal (Y-TZP) surfaces by immobilization of insulin-like growth factor 1 (IGF-1). Surface analyses by Fourier Transform Infrared Spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS) showed that IGF-1 was successfully immobilized on the Y-TZP surfaces. There was no significant difference between the number of cells attached to the IGF-1-immobilized Y-TZP surfaces and on the as-polished Y-TZP surfaces either at 3 or 72 h. However, IGF-1-immobilized Y-TZP surfaces yielded a significantly higher expression of integrin ?4 mRNA and laminin-5 mRNA, and enhanced adhesion strength of HGECs after 72 h of incubation. There was no difference between the amount of adhered Streptococcus gordonii (S. gordonii) found on the IGF-1-immobilized Y-TZP surfaces and on the as-polished Y-TZP surfaces. These results suggested that the IGF-1-immobilized Y-TZP surfaces developed using the method reported herein enhanced the adhesion and extension of HGECs to the Y-TZP surfaces without enhancing S. gordonii adhesion. This article is protected by copyright. All rights reserved.

PMID: 25845378 [PubMed – as supplied by publisher]

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