According to a news release from the American Thoracic Society, statin use may help prevent delirium in critically ill patients who took statins before entering the hospital.
“This is the first study using a validated delirium screening tool, the Confusion Assessment Method-ICU (CAM-ICU), to show that the administration of statins reduces delirium in these patients,” noted lead author Valerie J. Page of the Watford General Hospital in Watford, UK. “This benefit may be mediated by a reduction in systemic inflammation.”
Of the 470 patients that took part in the study, 151 were given statins. However, statins were only given to patients who had taken statins prior to entering the hospital.
After taking into consideration age, sex and illness severity, the use of statins the previous evening was linked with a much lower risk of delirium and a concomitant decline in serum C-reactive protein, an indicator of systemic inflammation, the following day.
“Although the pathogenesis of delirium is not fully understood, these data are consistent with a neuro-inflammatory cause and suggest that the anti-inflammatory effects of statins may contribute to the effects of statin treatment on delirium,” explained Page. “Our study on statin use and the risk of delirium in critically ill subjects included extensive data on a large, broadly representative population of consecutive intensive care patients, increasing its strength.”
The study authors note the possibility that not all likely confounding factors were taken into consideration.
“Our findings suggest that statin treatment should be continued to help prevent delirium in critically ill patients who received statins before being admitted,” concluded Page.
The study’s findings are described in greater detail in the American Journal of Respiratory and Critical Care Medicine.
“This is the first study using a validated delirium screening tool, the Confusion Assessment Method-ICU (CAM-ICU), to show that the administration of statins reduces delirium in these patients,” noted lead author Valerie J. Page of the Watford General Hospital in Watford, UK. “This benefit may be mediated by a reduction in systemic inflammation.”
Of the 470 patients that took part in the study, 151 were given statins. However, statins were only given to patients who had taken statins prior to entering the hospital.
After taking into consideration age, sex and illness severity, the use of statins the previous evening was linked with a much lower risk of delirium and a concomitant decline in serum C-reactive protein, an indicator of systemic inflammation, the following day.
“Although the pathogenesis of delirium is not fully understood, these data are consistent with a neuro-inflammatory cause and suggest that the anti-inflammatory effects of statins may contribute to the effects of statin treatment on delirium,” explained Page. “Our study on statin use and the risk of delirium in critically ill subjects included extensive data on a large, broadly representative population of consecutive intensive care patients, increasing its strength.”
The study authors note the possibility that not all likely confounding factors were taken into consideration.
“Our findings suggest that statin treatment should be continued to help prevent delirium in critically ill patients who received statins before being admitted,” concluded Page.
The study’s findings are described in greater detail in the American Journal of Respiratory and Critical Care Medicine.
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