: The antioxidative stress job of phosphoserine and phosphoserine peptides used to be examined the use of an in vitro adaptation of hydrogen peroxide (H2O2)-brought on oxidative stress in Caco-2 cells. Phosphoserine dimers (2PS) decreased IL-eight secretion in H2O2-handled Caco-2 cells, and lowered H2O2-caused expression of genes concerned with irritation and technology of reactive oxygen species (ROS), including Chemokine (C-C motif) ligand 5 (CCL5), Lactoperoxidase (LPO), Myeloperoxidase (MPO), Neutrophil cytosolic factor 1/ 2 (NCF1/2), and Nitric oxide synthase 2A (NOS2), and up-regulated Metallothionein 3 (MT3), Peroxiredoxin 3 (PRDX3), and Surfactant, pulmonary-associated protein D (SFTPD), which are involved in protection against oxidative stress and activation of the Nrf2 signaling pathway. At the protein level, 2PS reduced H2O2-induced phosphorylation of the ERK1/2 and JNK MAPKs, and increased Nrf2 expression. Furthermore, the power of 2PS to scale back H2O2-precipitated IL-eight secretion, a marker of irritation and oxidative stress, used to be abrogated in Nrf2 knock-down cells.
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